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If you still use immersion fluid for performing contact dermoscopy, you may have noticed that the 'Dermlite-branded' oil has recently been discontinued.
So what other options are out there?
Even prior to this recent product discontinuation, many dermoscopists had already shifted toward using isopropyl alcohol (rubbing alcohol) or alcohol-based gel as their preferred interface fluid — especially in clinical settings. These options are often considered more convenient because they are self-sanitizing, fast-drying, and easier to clean up between patients.
That said, some clinicians still prefer the traditional 'immersion oil' — especially for non-polarized contact dermoscopy where maximal optical clarity is needed. If you're one of those who prefers the classic approach, here's what to know about sourcing a suitable replacement.
The Key Characteristics of a Suitable Immersion Fluid
Traditionally, the characteristics of immersion oils have been:
- Colorless and odorless
- High-purity, non-irritating
- Low-viscosity, transparent fluids
Most branded immersion fluids — including the one previously available in our store — are based on a single core ingredient:
USP-Grade White Mineral Oil (CAS No. 8042-47-5)
This is a highly refined, pharmaceutical-grade oil that’s been used for decades in both medical and cosmetic applications due to its purity and optical clarity.
So if you're looking to replace your discontinued immersion oil, here’s what you should look for:
FEATURE |
REQUIREMENT |
WHY IT MATTERS |
Purity Grade |
USP (United States Pharmacopeia) |
Ensures safety, consistency, and no additives |
Viscosity |
Light/low viscosity (~15 cSt @ 40°C) |
Spreads easily and won’t smudge optics |
Optical Clarity |
Transparent, colorless |
Maintains image detail and light penetration |
Additive-Free |
No fragrance, dyes, or emulsifiers |
Reduces risk of skin irritation and residue |
Packaging |
Squeeze bottle or dropper preferred |
Minimizes waste, supports clean application |
Acceptable Alternatives
You don’t necessarily need a branded medical product. Alternatives include any high-purity USP white mineral oil which may be sold as:
- Cutting board conditioners
- Food-grade mineral oil
- Cosmetic-use light mineral oil
Look for labels with:
- “USP” or “Pharmaceutical Grade”
- “100% Pure Mineral Oil”
- “CAS 8042-47-5”
Pro Tip: Avoid industrial mineral oils or gear lubricants — they may contain additives and are not suitable for skin use.
What to Avoid
- Products with fragrance, vitamin E, aloe, or lanolin
- “Baby oils” (often scented or modified)
- Technical-grade or industrial mineral oil
- Heavy oils that leave residue or impede dermatoscopic imaging
Bottom Line: Here's What You Need
When it comes to finding an immersion oil for performing dermoscopy, it does not need to be marketed specifically as such. However, you should look for the following characteristics:
✅ USP White Mineral Oil
✅ Light viscosity
✅ No additives
✅ Transparent and colorless
As long as the oil you purchase has these qualities, it will closely match the performance of the previously sold immersion fluid.