Moth-eaten Border

Moth-eaten Border

Source: Dermoscopedia.Org, academy.dermoscopedia.org/Solar_lentigo. Accessed 23 Nov. 2024.

Histopathological Correlation: The moth-eaten border appearance is characterized by sharply demarcated, irregularly curved, and scalloped edges. This pattern is often due to the irregular infiltration or destruction of the lesion's border, which can be histopathologically correlated with uneven proliferation or distribution of melanocytes or keratinocytes at the lesion's periphery.

Other Names/Synonyms: The term "moth-eaten border" is specifically used to describe this irregular, scalloped appearance. 

Clinical Relevance: Moth-eaten borders are not exclusive to malignant lesions. While they can be indicative of melanoma, suggesting an invasive or aggressive growth pattern, they are also commonly seen in benign lesions such as solar lentigines and seborrheic keratoses.

Associated Lesions: This pattern is often associated with solar lentigines and flat seborrheic keratoses. It can also be seen in melanomas, where it may suggest a more aggressive or invasive growth pattern.

Variants or Related Patterns: The moth-eaten border is related to other irregular border patterns seen in malignant lesions. It is a specific type of irregular border that can be seen in both benign and malignant conditions.

Key Differentiators: Moth-eaten borders can be confused with other irregular border patterns. Clinicians can avoid misinterpretation by considering the overall clinical and dermoscopic context, including the presence of other dermoscopic features and the lesion's history. Recognizing that this pattern can occur in both benign and malignant lesions is crucial for accurate diagnosis.